Топ-100

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Akabori amino-acid reaction

There are several Akabori amino acid reactions, which are named after Shirō Akabori, a Japanese chemist. In the first reaction, an α-amino acid is oxidised and undergoes decarboxylation to give an aldehyde at the former α position by heating with ...

                                               

Albright-Goldman oxidation

The Albright-Goldman oxidation is a name reaction of organic chemistry, first described by the American chemists J. Donald Albright and Leon Goldman in 1965. The reaction is particularly suitable for the synthesis of aldehydes from primary alcoho ...

                                               

Aldol–Tishchenko reaction

The Aldol–Tishchenko reaction is a tandem reaction involving an aldol reaction and a Tishchenko reaction. In organic synthesis it is a method to convert aldehydes and ketones into 1.3-hydroxyl compounds. The reaction sequence in many examples sta ...

                                               

Algar–Flynn–Oyamada reaction

There are several possible mechanisms to explain this reaction, however, these reaction mechanisms have not been elucidated. What is known is that a two-stage mechanism exists. First, dihydroflavonol is formed, which then subsequently oxidized to ...

                                               

Allen–Millar–Trippett rearrangement

The Allen–Millar–Trippett rearrangement is a ring expansion reaction in which a cyclic phosphine is transformed into a cyclic phosphine oxide. This name reaction, first reported in the 1960s by David W. Allen, Ian T. Millar, and Stuart Trippett, ...

                                               

Amadori rearrangement

The Amadori rearrangement is an organic reaction describing the acid or base catalyzed isomerization or rearrangement reaction of the N -glycoside of an aldose or the glycosylamine to the corresponding 1-amino-1-deoxy-ketose. The reaction is impo ...

                                               

Angeli–Rimini reaction

The Angeli–Rimini reaction is an organic reaction between an aldehyde and the sulfonamide N-hydroxybenzenesulfonamide in presence of base forming a hydroxamic acid. The other reaction product is a sulfinic acid. The reaction was discovered by the ...

                                               

Appel reaction

The Appel reaction is an organic reaction that converts an alcohol into an alkyl chloride using triphenylphosphine and carbon tetrachloride. The use of carbon tetrabromide or bromine as a halide source will yield alkyl bromides, whereas using car ...

                                               

Arndt–Eistert reaction

In organic chemistry, the Arndt–Eistert reaction is the conversion of a carboxylic acid to its homologue. Named for the German chemists Fritz Arndt and Bernd Eistert, the method entails treating an acid chlorides with diazomethane. It is a popula ...

                                               

Asinger reaction

The Asinger-reaction is a multicomponent reaction for the synthesis of 3-thiazolines and other related heterocycles. It is named after Friedrich Asinger who first reported it in 1956.

                                               

Atherton–Todd reaction

The Atherton-Todd reaction is a name reaction in organic chemistry, which goes back to the British chemists F. R. Atherton, H. T. Openshaw and A. R. Todd. These described the reaction for the first time in 1945 as a method of converting dialkyl p ...

                                               

Aza-Baylis–Hillman reaction

The aza-Baylis–Hillman reaction or aza-BH reaction in organic chemistry is a variation of the Baylis–Hillman reaction and describes the reaction of an electron deficient alkene, usually an α,β-unsaturated carbonyl compound, with an imine in the p ...

                                               

Aza-Cope rearrangement

Rearrangements, especially those that can participate in cascade reactions, such as the aza-Cope rearrangements, are of high practical as well as conceptual importance in organic chemistry, due to their ability to quickly build structural complex ...

                                               

Aza-Diels–Alder reaction

The aza-Diels–Alder reaction converts imines and dienes to tetrahydropyridines. This organic reaction is a modification of the Diels–Alder reaction. The nitrogen atom can be part of the diene or the dienophile. The imine is often generated in sit ...

                                               

Azide-alkyne Huisgen cycloaddition

The azide-alkyne Huisgen cycloaddition is a 1.3-dipolar cycloaddition between an azide and a terminal or internal alkyne to give a 1.2.3-triazole. Rolf Huisgen was the first to understand the scope of this organic reaction. American chemist Karl ...

                                               

Baeyer–Villiger oxidation

The Baeyer–Villiger oxidation is an organic reaction that forms an ester from a ketone or a lactone from a cyclic ketone, using peroxyacids or peroxides as the oxidant. The reaction is named after Adolf von Baeyer and Victor Villiger who first re ...

                                               

Baker–Venkataraman rearrangement

The Baker–Venkataraman rearrangement is the chemical reaction of 2-acetoxyacetophenones with base to form 1.3-diketones. This rearrangement reaction proceeds via enolate formation followed by acyl transfer. It is named after the scientists Wilson ...

                                               

Bamberger rearrangement

The Bamberger rearrangement is the chemical reaction of phenylhydroxylamines with strong aqueous acid, which will rearrange to give 4-aminophenols. It is named for the German chemist Eugen Bamberger. The starting phenylhydroxylamines are typicall ...

                                               

Bamford–Stevens reaction

The Bamford–Stevens reaction is a chemical reaction whereby treatment of tosylhydrazones with strong base gives alkenes. It is named for the British chemist William Randall Bamford and the Scottish chemist Thomas Stevens Stevens. The usage of apr ...

                                               

Banert cascade

The Banert cascade is an organic reaction in which an NH-1.2.3-triazole is prepared from a propargyl halide or sulfate and sodium azide in a dioxane- water mixture at elevated temperatures. This cascade reaction is unusual because it consists of ...

                                               

Barbier reaction

The Barbier reaction is an organometallic reaction between an alkyl halide, a carbonyl group and a metal. The reaction can be performed using magnesium, aluminium, zinc, indium, tin, samarium, barium or their salts. The reaction product is a prim ...

                                               

Barton reaction

The Barton reaction, also known as the Barton nitrite ester reaction, is a photochemical reaction that involves the photolysis of an alkyl nitrite to form a δ-nitroso alcohol. Discovered in 1960, the reaction is named for its discoverer, Nobel La ...

                                               

Barton–Kellogg reaction

The Barton–Kellogg reaction is a coupling reaction between a diazo compound and a thioketone, giving an alkene by way of an episulfide intermediate. This reaction was pioneered by Hermann Staudinger, and also goes by the name Staudinger type diaz ...

                                               

Barton–McCombie deoxygenation

The Barton–McCombie deoxygenation is an organic reaction in which a hydroxy functional group in an organic compound is replaced by a hydrogen to give an alkyl group. It is named after British chemists Sir Derek Harold Richard Barton and Stuart W. ...

                                               

Barton–Zard reaction

The Barton–Zard reaction is a route to pyrrole derivatives via the reaction of a nitroalkene with an α-isocyanoacetate under basic conditions. It is named after Derek Barton and Samir Zard who first reported it in 1985.

                                               

Baudisch reaction

In organic chemistry, the Baudisch reaction is a process for the synthesis of nitrosophenols using metal ions. Although the products are of limited value, the reaction is of historical interest as an example of metal-promoted functionalization of ...

                                               

Baylis–Hillman reaction

The Baylis–Hillman reaction is a carbon-carbon bond forming reaction between the α-position of an activated alkene and a carbon electrophile such as an aldehyde. Employing a nucleophilic catalyst, such as a tertiary amine and phosphine, this reac ...

                                               

Beckmann rearrangement

The Beckmann rearrangement, named after the German chemist Ernst Otto Beckmann, is a rearrangement of an oxime functional group to substituted amides. The rearrangement has also been successful performed on haloimines and nitrones. Cyclic oximes ...

                                               

Benkeser reaction

The Benkeser reduction reaction is the hydrogenation of polycyclic aromatic hydrocarbons, especially naphthalenes using lithium or calcium metal using low molecular weight alkyl amines as the solvent and, in part, as a source of protons. This rea ...

                                               

Bergman cyclization

The Bergman cyclization or Bergman reaction or Bergman cycloaromatization is an organic reaction and more specifically a rearrangement reaction taking place when an enediyne is heated in presence of a suitable hydrogen donor. It is the most famou ...

                                               

Bergmann degradation

The Bergmann degradation is a series of chemical reactions designed to remove a single amino acid from the carboxylic acid end of a peptide. First demonstrated by Max Bergmann in 1934, it is a rarely used method for sequencing peptides. The later ...

                                               

Betti reaction

The Betti reaction is a chemical addition reaction of aldehydes, primary aromatic amines and phenols producing α-aminobenzylphenols. The Betti reaction is a special case of the Mannich reaction.

                                               

Biginelli reaction

The Biginelli reaction is a multiple-component chemical reaction that creates 3.4-dihydropyrimidin-2-ones 4 from ethyl acetoacetate 1, an aryl aldehyde, and urea 3. It is named for the Italian chemist Pietro Biginelli. This reaction was developed ...

                                               

Bingel reaction

The Bingel reaction in fullerene chemistry is a fullerene cyclopropanation reaction to a methanofullerene first discovered by C. Bingel in 1993 with the bromo derivative of diethyl malonate in the presence of a base such as sodium hydride or DBU. ...

                                               

Birch reduction

The Birch reduction is an organic reaction that is used to convert arenes to cyclohexadienes. The reaction is named after the Australian chemist Arthur Birch. In this organic reduction of aromatic rings in liquid ammonia with sodium, lithium, or ...

                                               

Bischler–Mohlau indole synthesis

The Bischler–Mohlau indole synthesis, also often referred to as "The Bischler Indole Synthesis," is a chemical reaction that forms a 2-aryl-indole from an α-bromo-acetophenone and excess aniline; it is named after August Bischler and Richard Mohl ...

                                               

Bischler–Napieralski reaction

The Bischler–Napieralski reaction is an intramolecular electrophilic aromatic substitution reaction that allows for the cyclization of β-arylethylamides or β-arylethylcarbamates. It was first discovered in 1893 by August Bischler and Bernard Napi ...

                                               

Blaise reaction

The Blaise reaction is an organic reaction that forms a β-ketoester from the reaction of zinc metal with a α-bromoester and a nitrile. Bulky aliphatic esters tend to give higher yields. Steven Hannick and Yoshito Kishi have developed an improved ...

                                               

Blanc chloromethylation

The Blanc chloromethylation is the chemical reaction of aromatic rings with formaldehyde and hydrogen chloride catalyzed by zinc chloride or other Lewis acid to form chloromethyl arenes. The reaction was discovered by Gustave Louis Blanc in 1923. ...

                                               

Bobbitt reaction

The Bobbitt reaction is a name reaction in organic chemistry. It is named after the american chemist James M. Bobbitt. The reaction allows the synthesis of 1-, 4-, and N -substituted 1.2.3.4-tetrahydroisoquinolines and also 1-, and 4-substituted ...

                                               

Bohn–Schmidt reaction

The Bohn–Schmidt reaction, a named reaction in chemistry, introduces a hydroxy group at an anthraquinone system. The anthraquinone must already have at least one hydroxy group. The reaction was first described in 1889 by Rene Bohn and in 1891 by ...

                                               

Borsche–Drechsel cyclization

The Borsche–Drechsel cyclization is a chemical reaction used to synthesize tetrahydrocarbazoles by the acid-catalyzed cyclization of cyclohexanone arylhydrazones. The reaction was first described by Edmund Drechsel in 1888 and by Walter Borsche i ...

                                               

Bosch reaction

The Bosch reaction is a chemical reaction between carbon dioxide and hydrogen that produces elemental carbon, water, and a 10% return of invested heat. It is named after the German chemist Carl Bosch. This reaction requires the introduction of ir ...

                                               

Bouveault aldehyde synthesis

The Bouveault aldehyde synthesis is a one-pot substitution reaction that replaces an alkyl or aryl halide with a formyl group using a N, N -disubstituted formamide. For primary alkyl halides this produces the homologous aldehyde one carbon longer ...

                                               

Bouveault–Blanc reduction

The Bouveault–Blanc reduction is a chemical reaction in which an ester is reduced to primary alcohols using absolute ethanol and sodium metal. It was first reported by Louis Bouveault and Gustave Louis Blanc in 1903. Bouveault and Blanc demonstra ...

                                               

Boyland–Sims oxidation

The Boyland–Sims oxidation is the chemical reaction of anilines with alkaline potassium persulfate, which after hydrolysis forms ortho -hydroxyl anilines. The ortho -isomer is formed predominantly. However, the para -sulfate is formed in small am ...

                                               

Bray–Liebhafsky reaction

The Bray–Liebhafsky reaction is a chemical clock first described by William C. Bray in 1921 and the first oscillating reaction in a stirred homogeneous solution. He investigated the role of the iodate, the anion of iodic acid, in the catalytic co ...

                                               

Brook rearrangement

In organic chemistry the Brook rearrangement refers to any carbon to oxygen silyl migration. The rearrangement was first observed in the late 1950s by Canadian chemist Adrian Gibbs Brook, after which the reaction is named. These migrations can be ...

                                               

Bucherer reaction

The Bucherer reaction in organic chemistry is the reversible conversion of a naphthol to a naphthylamine in the presence of ammonia and sodium bisulfite. The reaction is widely used in the synthesis of dye precursors aminonaphthalenesulfonic acid ...

                                               

Bucherer–Bergs reaction

The Bucherer–Bergs reaction is the chemical reaction of carbonyl compounds or cyanohydrins with ammonium carbonate and potassium cyanide to give hydantoins. The reaction is named after Hans Theodor Bucherer. Overall Reaction